Second and third meet in division one's match of the round as East Coast makes the trip up to Old Launcestonians.
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The pair had contrasting results last week, with East Coast the victorious one and coach Gene Savage is eager to see how his side shapes up.
"The boys are really excited and looking forward to another challenge on the road," he said.
"We have a good support base that come to our away games, so that's fantastic for the players and I'm sure Saturday will be no different."
OLs coach Laine Cleaver described last week's loss as "a wake up call" but it wasn't all doom and gloom, using the experience to see where they are against the benchmark.
"East Coast are in some good form, they've only lost to Lilydale themselves and obviously a couple of weeks ago Scotch beat Lilydale and then East Coast beat Scotch, so they are playing some good football," he said.
Former AFL star Jay Schulz will suit up, coming in alongside Pat Kearney as Jesse Brown and Will Searle make way.
Two sides floating around the middle of the table, Bridport and St Pats, do battle in an important match for both.
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After winning in a physical contest last week, St Pats coach Jake Lowe is wary of the Seagulls.
"They are always better at their home ground and we've both got a lot to play for," he said.
"It's obviously only midway through the season, but I think both sides are pretty uncertain on where we stand against each other, so we are really excited to go down there and have a crack at it."
Lowe brings back late withdrawal Jye Balym and Jed Steele, while Bridport's injury woes ease with Cody Kerrison and Matthew Taylor returning.
Getting back on the winners' list, coach Greg Latham described last week as the Seagulls' most consistent performance ahead of Saturday's challenge.
"We expect them to be top three or four, so there are always a difficult opponent, but [being] at our home ground and with the expectation that we might get one or two back finally, hopefully it's going to be a close game."
Old Scotch also welcomes back a handful of stars to take on UTAS.
James De Boer, Will Harper, Tom Pedley and Charlie Eastoe are all in the mix to come back after the side's second loss, which coach Brayley Coombes hopes the Thistles will learn from.
"We are working on some things structurally that's going to stack up at the pointy end of the season, so we just need to continue having a few teething problems," he said.
UTAS will be without coach Brodie Tiernan (broken hand) and gun Chris Smith but Tiernan said the signs have encouraging over the past few weeks.
"They are obviously playing some pretty good footy and we have a few injuries as well which doesn't help," he said.
"It's going to be tough, but we seem to play better against tougher teams, in the last few weeks, the feedback from East Coast and Lilydale has been that we've improved."
The battle for eighth and ninth takes an interesting turn as Perth hosts Evandale.
Competitive against St Pats in the first half, Danny Bennett knows his side can be strong against top-tier outfits and hopes to improve their consistency, starting with the Eagles.
"We'll go into the game reasonably confident but Evandale are a similar side to us, they are young, on the up and have got a good coach there," he said.
"I'm sure they've been working hard and no doubt they see a winnable game for them as well which should be a competitive contest."
LAST WEEK'S NTFA
Using last weekend's maiden win as "reinforcement that what we are doing is right", Eagles coach Sam Bouwman has had his side battered by injuries yet again.
Jackson Davey, Kieran Carlton and Tyler Brown are all in doubt but Bouwman remains positive.
"It's a team that is in our bracket and a team that we feel we are in a similar spot as, so it's a good chance to test us and there's a big rivalry between the two towns too - I know there's a lot of history there as well," he said.
Another side struggling with injuries, Meander Valley, gets the chance to give its youth a major test against Lilydale on the Demons' home turf.
Suns coach Damien Rhind has been developing younger players, strapping himself in to the rollercoaster that comes with doing so.
"It's a great opportunity for a lot of our younger players to put themselves up against a side that over the last couple of years has been the competition benchmark," he said.
"It'll be a personal challenge for the young guys to put themselves up against those players and the challenge for the experienced players is to make sure we support them in the best way we can."
Lilydale regain Sonny Whiting, Sam Lockett, Jarrod Foale and Beau Tuthill, giving Colin Lockhart some selection headaches.
Lockhart is hoping for his side to use their pace to their advantage, with quick forward entries key.
"We have to go in confident because of where we are sitting ... but it is one week at a time and we aren't getting too ahead of ourselves," he said.