Ladder-leaders Lilydale have no idea what to expect against St Pats, a 2019 grand final rematch on paper.
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The sides only face each other once this year, with Demons coach Colin Lockhart trying to produce strong outside run like they did last week.
"They are a totally different side, so it's a real unknown for us about them," he said.
"The people that they've got that didn't play in the grand final is probably more than what did, so it's not really a grand final rematch."
The reigning premier welcomes back Sonny Whiting and Sam Cooke to help up forward, while St Pats could have six changes, with key personnel missing last week.
"We've been focusing on a few structural things that we've put in place and with more than 20 new players in our senior group, we've started to gel in the last month," coach Jake Lowe said.
"Lilydale are a very good outfit and have been very good for a number of years, so it's going to be a tough game."
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Two sides on the precipice of the top five, Perth and Bridport, do battle as they hope to close the gap.
Both sit two wins away from finals with Bridport holding the superior percentage, but Greg Latham isn't taking the Magpies lightly.
"It's a significant challenge, not only because we are at similar spots on the ladder, but [also] given our situation with injuries at the moment," he said.
"There's nothing you can do about that [though], we put 22 on the park and we see how we go."
The Seagulls lost three more to injury last week, while Danny Bennett's Perth welcomes back Kalyn Eady after defeating Evandale for the first time since 2012.
Bennett is hoping to bring a consistent brand of football, with his side showing what they are capable of for short bursts.
"Bridport seem to be tracking along ok - similar to us," he said.
"They are always hard to beat, we look forward to the challenge and hopefully we can get back-to-back wins."
Taking a lot from last week's loss to Perth, Evandale coach Sam Bouwman is well aware of the challenge ahead against Old Scotch.
"It's a massive challenge but a good one for a young group though," he said.
"We've got a lot of guys who are developing their footy and one of the best ways to learn is to play against the best and I think Old Scotch are going to be right up there."
Bouwman joined Evandale's injury curse on the weekend, while Old Scotch welcomes back ruckman George Oliver, with coach Brayley Coombes pleased with his side's depth, putting pressure on training and selection.
"We've had a few injuries over the last three to four weeks, none of those long term, so we are starting to regain them and we've had a few newer players which have rolled in later throughout the season," he said.
"So our depth is starting to shine and that means we can introduce some guys to our systems and see how they go as well."
A similar challenge awaits UTAS, with the Lions ready to face Old Launcestonians.
Dealing with 10 changes last week, injured coach Brodie Tiernan is hoping to learn from this week's contest.
"All the good teams play quite similarly, so we obviously want to incorporate things into our game that they do," he said.
"Attitude is something we look at as well, it's quite easy when you get beat by 200 points for guys to be deflated, so we try and keep that as positive as we can."
For Old Launcestonians' Laine Cleaver, it's business as usual, with his Blues dropping down the ladder despite a big win due to Old Scotch's superior percentage.
"We need to come out and have a solid win in case it gets to the end of the year and percentage plays a part in where we finish on the ladder," he said.
Meander Valley coach Damien Rhind was extremely pleased with his side's first half against Lilydale, but is looking for a sustained effort as the Suns make the trip to face East Coast.
"It's a massive ground down there, so we will be looking to be making good decisions when we have the ball and certainly containing their run to stop them from opening up the game," he said.
Coming off a rare rough loss, East Coast coach Gene Savage said his side learned a lesson to "not take things too lightly" against competitive sides.
"We're just looking to get back to the form we captured in the last month or so and just get back to basics and work hard," he said.
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