Emergency services were called to Lemonwood Street about 7.15pm after the man lost control of the Suzuki road bike and sustained injuries.

Inspector Craig Fox said the man's condition was not considered critical upon their arrival as there were no visible serious injuries, but he quickly deteriorated.

"The man was talking, he was responsive, he was engaging with witnesses, family and police, Tasmania Ambulance was called as a precaution as we do for most traffic accidents," he said.

"Unfortunately and tragically, soon after, that man had a deterioration in his condition. He was worked upon by paramedics at the scene, but unfortunately he was pronounced dead soon after."

The street was closed for three hours and crash investigations are ongoing, with toxicology reports to also occur. Police believe the man was wearing a helmet at the time, the motorcycle belonged to a friend of his and he was considered an experienced rider.

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Inspector Fox said it was too early to provide detailed information about the moments leading up to the crash, except that it appeared the man lost control while travelling along Lemonwood Street and was thrown from the motorcycle, sustaining serious internal injuries.

"The driving behaviour of the rider is going to be a key component of the investigation," he said.

"Our investigation so far indicate that he came off the bike close to a residence, and as a result of coming off the bike he was thrown several metres and struck a parked car."

The man was a resident of the street, and family and friends were quickly on the scene.

"It was a very emotional scene, police accept that, we understand that family and friends are going to be asking questions and are going to be very upset," Inspector Fox said.

The crash brings Tasmania's road toll to 23 for 2021, above average for the year to August. The 10-year average is 32.

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There have been numerous fatal crashes on Tasmanian roads since July, including a head-on crash at Glenora on August 8, single vehicle crashes on King Island on July 29, Richmond on July 26 and Mount Direction on July 9, and a double fatality on the Bass Highway at Exton on July 10.

Inspector Fox said it was vital that drivers were safe on the roads to protect themselves and others.

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"You can't expect a police officer to be around every corner, so there's an onus of responsibility on drivers and riders here that they have to drive to the conditions," he said.

"They have to drive to their own experience levels, and don't put themselves and other road users at an unnecessary risk."

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