The changes which were announced last Friday are aimed at creating more 'job-ready' graduates and will see the creation of 39,000 new university places by 2023.

They will also see funding per student fall across the majority of courses.

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Tasmania University Union president Braydon Broad said it is hard to see how the changes won't negatively impact students.

"The irony has not escaped many of our attention that a lot of the people proposing these changes benefit from paying very little for their university degrees," he said.

He urged crossbenchers, who may hold the balance of power in the Senate, not to support the bill.

"Listen to the students... we are aware of Facebook groups that are popping up of Year 11 and Year 12 students and we know they are planning to organise action against this," Mr Broad said.

"Your student constituents are the ones who surely should have the most sway over this issue."

Labor senator for Tasmania Helen Polley said the proposed changes were concerning.

"I have had young people ringing my office who are concerned that they will not be able to go on, even if they get their scores, to study the courses of their choice and that's wrong," she said.

She said it will limit the number of young people from regional areas who will have access to university education.

Education Minister Dan Tehan defended the proposed changes.

He said they would help improve the student experience and provide better access to universities for regional students.

"We are setting up a new fund which will have 500 million a year in it which will go to universities for programs which student Indigenous, regional and low socio-economic students," Mr Tehan said.

A spokesperson for the University of Tasmania is working to model the impacts of the changes on the university.