It is understood four full-time-equivalent positions are to be removed from teaching staff numbers.

The school provides online education programs for children who need to study by distance and innovative programs that cater to complex needs.

This includes programs for children with a disability and those that cannot step into a classroom in a mainstream school.

Some children have a dual-enrolment at eSchool and another school while others attend the school as a pathway to a mainstream classroom.

Tasmanian Disability Education Reform Lobby spokeswoman Kristen Desmond said programs would be impacted if staff were reduced.

She said a staff reduction was tried four years ago and enrolments had since increased by 100.

"We have kids that have gone through eSchool that went on to become apprentices because they stayed engaged with learning," Ms Desmond said.

"For some kids, this is their school. This is their identity.

"This is a school of last resort for some children."

Tasmanian eSchool school association chairman, Ben Cunningham, said the association was not consulted about the planned staff cuts.

He said the decision was made as it was believed the school was overstaffed.

Mr Cunningham said prep, grade 1 and grade 2 levels would be rolled into one though believed this move would not give children the best support for their acute needs.

"The numbers are low at the moment but will fluctuate," he said.

"Historically, every year the numbers increase."

A government spokesperson said fluctuations in staffing numbers were common and based on students enrolments and specific needs.

"The eSchool will continue to maintain teaching staff above the 2016 eSchool Review recommendations," they said.

"Further, there are additional eSchool support staff, including school psychologists and social workers with teacher assistant hours also been increased.