Convicted murderer Sue Neill-Fraser's defence team has submitted its closing argument to Hobart's Supreme Court, telling a panel of judges an appeal should be allowed and a retrial ordered.
Neill-Fraser is serving 23 years' jail for the murder of her defacto partner Bob Chappell who disappeared from his yacht Four Winds on January 26 in 2009.
Evidence closed early on Wednesday after it was decided a witness, Paul Holloway, to testify over DNA found onboard the vessel would not be required.
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Defence lawyer Chris Carr said reports and evidence submitted by forensic scientist Maxell Jones during a leave application hearing for the appeal would be heavily relied upon in their argument.
He said the case presented by the Director of Public Prosecutions in the 2010 trial was circumstantial.
"The real issue at trial is whether the prosecution excluded any reasonable hypothesis of innocence," Mr Carr said.
He said it was a reasonable hypothesis that Meaghan Vass and companions visited the yacht that night in a grey dinghy given her DNA was found on the yacht.
Ms Vass denied at the trial and in the appeal hearings this week that she was on the vessel the night Mr Chappell disappeared and that she had been pressured to say she had been.
Mr Carr said the defence team would rely on Mr Jones' evidence as satisfying a requirement for there to be fresh and compelling evidence to allow an appeal to be heard.
In the leave application hearing, Mr Carr said Mr Jones had elaborated on the probability of the prosecution's argument that secondary transfer of Ms Vass' DNA had occurred.
He said this had not happened at the trial.
Mr Carr said Mr Jones had outlined "quite specific and a remarkable number" of coincidences and chain of events for secondary transfer to have occurred.
"That explanation is entirely inconsistent with the way that was put to the jury in the trial," he said.
Director of Public Prosecutions Daryl Coates will submit his closing argument once the court reopens after an adjournment.