Invermay Road is set for a $2.9 million upgrade this month, between Forster Street and Vermont Road.
It will involve the reseal of the 2.1 kilometre section, kerb and channel repair, and new line marking, signage and traffic islands.
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The work is due to start on February 15 and will take about three months to complete.
Launceston mayor Albert van Zetten said the road's surface had reached the end of its useful life.
"Like some other roads around Launceston, sections of Invermay Road are built over concrete slabs from the trolley bus era. This adds to the complexity of the project, as we need to ensure that the joins in the concrete do not reflect through the new asphalt seal," he said.
"Because Invermay Road is a significant transport corridor, the works will result in delays for road users from time to time, but we will attempt to minimise these wherever possible.
"We hope all road users will obey any temporary speed limit changes that may be in place during the works, and we look forward to seeing the project complete later this year."
Two-way traffic will be maintained throughout the works, but reduced speed limits and traffic management will be in place.
The roadworks are set to take place during the day, night and on weekends.
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