The Midland Highway is now open to light vehicles in both directions near Ross, after a multiple vehicle crash resulted in fatalities.
Motorists are advised to expect delays.
It is understood two vehicles were involved.
The crash was reported to authorities just before 1pm.
Tasmania Police said a single vehicle rollover has also been reported on the Tasman Highway at Apslawn, north of Swansea.
Three people have been taken to hospital. There are no details on their condition or injuries.
Further details to come.
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