A building at a high school in Glenorchy sustained substantial damage in a suspicious fire last night.
Emergency services were called to Cosgrove High School about 8pm on Saturday with an area of the school "well alight".
A "large amount of smoke" was emanating from a building, Tasmania Police said in a statement.
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"TFS brought the fire under control and it was contained to one building," the statement reads.
"However, there has been a substantial amount of damage caused to this section of the school."
Police are continuing to investigate the fire.
Anyone with information can contact Crime Stoppers on 180 333 000.