Tasmania Fire Service attended a structure fire at Rocherlea in the early hours of Sunday.
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A spokeswoman said the fire had been deemed deliberate and has been handed over to Tasmania Police for investigation.
Emergency services were called to a Cupania Street property about 4am.
It is the second time it has been targeted.
An hour earlier, fire crews in the South were called to a structure fire at Bridgewater.
Crews arrived to find half of the house engulfed in flames.
"Fire crews wearing breathing apparatus entered the house to extinguish the fire and search for the occupants. Fortunately no one was at home at the time of the fire," Tasmania Fire Service said.
"Crews rapidly brought the fire under control. Owing to the ferocity of the fire, the house sustained considerable structural damage and will possibly require demolition."
Investigation into the cause of the fire is underway, with the expected damage bill about $250,000.
"With daylight savings ending shortly and winter approaching it is a timely reminder to check your smoke alarms and replace the batteries if needed," TFS said.