Approximately 11,000 people who have arrived in Tasmania from Queensland since July 17 at 12.01am are required to self-isolate from 6pm Saturday night until Tuesday evening.
Those people affected are allowed to leave home for work and study only when it cannot be done from home, exercise in a 5km radius from their home or shop for essential goods - one person per household, and masks are required.
Anybody affected who has a booking for a COVID-19 vaccine before Wednesday is required to contact Public Health and change their appointment time.
The change has been put in place due to the highly infectious nature of the Delta variant - deputy director of Public Health Dr Scott McKeown said the situation was concerning and serious.
With the Greater Brisbane area going into a three-day lockdown due to a spike in COVID-19 cases, Premier Peter Gutwein has confirmed borders will shut to the affected areas from 4pm Saturday.
"As of 4pm today, Queensland will go into a snap three-day lockdown," he said.
"That will be a Level 2 set of restrictions which will mean that for those Tasmanians that are still in Brisbane at the moment, they will be able to come back but they will need to quarantine at suitable premises."
The local government areas of Brisbane City, Moreton Bay, Gold Coast, Ipswich, Lockyer Valley, Logan City, Noosa Shire, Redland City, Scenic Rim, Somerset and Sunshine Coast are locked out.
Sunday's AFL match at UTAS Stadium between Hawthorn and Brisbane is not set to be affected by the change.
"My understanding is at the moment, the advice I'm getting, we're confident that the game can go ahead on the basis that players have already left Brisbane as I understand, they are on a charter flight, they've been in a bubble and my understanding is they have been tested twice now in the last four days," Mr Gutwein said.
"At this stage the game is going ahead, but we'll take further advice during the day from Public Health."
Queensland has recorded six new locally-acquired cases linked to an Indooroopilly High School student, prompting a three-day lockdown of a large section of the state.
Meanwhile, NSW has reported 210 new locally acquired cases of COVID-19 and at least 32 of those people were circulating in the community for all or part of their infectious period.
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