Tasmania Fire Service is responding to reports of a structure fire located in the area of Brisbane and Margaret Streets, Launceston.
A neighbour said a man and woman, who were believed to be tenants, were being looked after by paramedics.
"The man who lives there is always really friendly and we say hello to each other every morning. We have car accidents on this street sometimes, but there hasn't been a fire here for as long as I can remember," they said.
Police and TFS remain on the the scene and request that motorists avoid Brisbane and Margaret Streets for the next few hours.
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