Launceston and East Devonport are being suggested for a vaping pilot program by business groups who say it is time for a "real-world trial" in Tasmania.
They appear unlikely to gain government support, and will push their idea to MLCs.
"Our current smoking rates are appalling," Tasmanian Chamber of Commerce and Industry chief executive Michael Bailey said.
"What have we possibly got to lose by piloting something that he been shown to work elsewhere in the world?
"Right around the world, nicotine vaping and nicotine e-cigarette products have been shown to be effective smoking cessation aids, including in places like the United Kingdom, the European Union and Japan.
"Recently, they have been legalised in New Zealand.
"Public Health England states nicotine vaping and e-cigarettes are 95 per cent less harmful than traditional cigarettes."
The TCCI and the Tasmanian Small Business Council will call for a pilot in a joint submission to a Legislative Council investigation into rural health services.
They have suggested East Devonport (smoking rate 23.1 per cent), Launceston (18.3 per cent), Bridgewater (43 per cent) and Risdon Vale (34.4 per cent) for pilots.
Sale of nicotine containing e-cigarettes is illegal across Australia.
From October 1, importation of nicotine e-cigarettes and liquid nicotine for vaping to Australia needs a doctor's prescription.
GPs in Tasmania will be able to prescribe e-cigarettes if they choose, and pharmacies wanting to dispense them will need a licence.
"The Tasmanian government does not support e-cigarettes, based on advice from global health experts that the evidence is not settled on the effectiveness of a personal vaporiser product to aid smoking cessation compared to other available evidence-based products," Health Minister Jeremy Rockliff said in September.
"Nicotine e-cigarettes have also been associated with immediate harms, including respiratory illness and burns, and the health effects of long-term use remain unclear.
"They are addictive and have the potential to reverse recent gains made to reduce the smoking rate in our state and re-normalise smoking within the community, which is an unacceptable risk.
"The government will consequently not be changing our strict regulation of e-cigarettes."
Mr Bailey said Tasmania had the highest smoking rate of any Australian state (17.6 per cent).
"This terrible rate affects people's health, our health system and is a punishing weight on our economy", he said.
"It's clear that the current toolkit of actions against smoking - higher taxes and more and more on public education - has run its course, and stronger and more radical action is required.
"We envisage the pilot program would be geographically limited to some of the areas with the highest smoking rates, with nicotine e-cigarette and vaping products made available to licensed tobacconists to offer as an alternative to existing smokers seeking to buy cigarettes.
"Having them stocked by licensed tobacconists for existing smokers only would ensure that the products are only available to people over the age of 18, and would prevent youth uptake."