Police were called to the scene at Top Gawler Road about 10.50pm following a report that a Holden Commodore sedan had failed to follow a right-hand bend in the road.
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The car then crashed head-on into a tree after verging off the road.
Police said the driver, who was the only person in the car, was flown to hospital in a serious condition.
They are currently investigating the cause of the single-vehicle crash.
MORE TO COME.