Forced back to regional level after North Launceston and Kingborough departed the State League, the Blues were allowed to keep just 11 of the last year's premiership team.

Yet for all their dominance last season, there's no guarantee the new-look Blues will begin season 2021 where 2020 left off.

Mikayla Binns' Blues face one of the league's toughest challenges first up - fellow flag favourite Old Scotch - whom many coaches rate as one of the league's toughest sides.

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Cabel Hall, who has led Scottsdale to four consecutive grand finals, said this season's premiership race was anything but clear-cut.

"It's certainly not just Launceston we're wary about, we understand that Old Scotch for instance have got nine Tassie Devils girls in their squad - they're going to be very hard to beat," Hall said.

"I think probably Old Scotch will be the team that's hardest to beat in fact, and we can't discount South Launceston as well.

"So there's plenty of strong teams - the competition has gone to another level which is great for women's footy and great for the growth of the game."

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Saturday's 11am Windsor Park clash will see premiership defender Binns - also a two-time grand finalist with Scottsdale - lead the Blues for the first time.

Binns predicted Tassie Devil Kelsie Hill, who returns from a broken arm, and older sister Georgia would have a big impact for a significantly less-experienced Blues side throughout the season.

"We're excited to start playing, it's been a long pre-season getting into the swing of things with the NTFA," Binns said.

"I think they're [Old Scotch] going to be really tough competition to be honest.

"They're a fit young bunch so I'm really excited to give them a crack and see how we go with it."