Tasmania Police are searching for a man and a woman in the South Riana area.
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The Westpac rescue helicopter is involved in the search which began earlier this afternoon.
The man is described as being aged about 35, white with a goatee, mousey brown hair, about 174cm tall, wearing a grey hoodie driving a white Toyota Hilux single-cab flat-tray ute.
The woman is about 40-years-old, white with dark brown or black hair with one side shaved, tattoos on her forearms, and wearing a puffer vest with fur around the hood, black tights and pink gum boots.
The woman was last seen at the South Riana shop about 2pm.
Anyone with information about either person should contact Tasmania Police on 131 444 or report to Crime Stoppers on 1800 333 000.