St Pats' match-up against UTAS will be extra special this week, marking 250 senior games for Tim Faul.
Debuting for the Saints in 2004, a senior premiership has eluded Faul throughout his career but they are one of the highly-favoured clubs this season.
Coach Jake Lowe is hoping his side can improve on their skill execution from last week's loss despite taking several positives out of it.
"We had a few focuses last week and out of five of them we probably delivered on two, so we are going in with a very similar five key focuses," Lowe said.
"Nothing really changes despite what the results have been for UTAS over the last couple of years, that's completely out of our control."
For UTAS coach Brodie Tiernan, the clash is about building the style of play the Lions need after showing glimpses of it last week in a strong team effort.
"We get to try what we've been practicing and learning against one of the top sides in the competition so it will be good to sort of gauge where we sit amongst the top guys as well," he said.
Old Launcestonians' depth will be tested against Evandale on Saturday, with coach Laine Cleaver forced to make eight changes through unavailability.
The Blues lost their opening match, with Cleaver identifying skill and communication errors throughout.
"We've been focusing on our skill execution under pressure situations, [to] stop the fumbles," he said.
"Hopefully we can work into the game and just move the ball around a bit better, give our forwards more options and get more work rate defensively from our mids."
With the Eagles also hoping to avoid going 0-2, coach Sam Bouwman wants to improve their stoppage work after starting well last week.
"We were soundly beaten across the whole game and even when we got our hands on the footy, we were beaten on the outside against Bridport," he said.
"We want to make sure we are in it for the four quarters rather than just the first half like last week."
Despite wins last week, the coaches of Lilydale and Bridport both left their games with things to work on.
Colin Lockhart feels his side isn't as fit as they could be while Bridport's Greg Latham thought the Seagulls went away from their game style, something they can't do this week.
"Certainly they appear to again be the team to beat but we welcome the challenge and we can only learn from it. We go out there, it's a 50-50 contest and we will see what happens," he said.
After losing Calum Aalbregt and Wil Lockhart, the Demons will bring in Trent Griggs while potentially looking to the likes of Sonny Whiting and Bailey Hawes as they celebrate 100 years.
"For this game, we requested Bridport for our 100th year, when I came out here in '92 it was always a hard road trip going out to Bridport," he said.
"They've got a couple of really good players in Jarrah [Burns] and Cody Kerrison - they are a quality outfit."
East Coast coach Gene Savage is keen for his side to have a huge following, hosting its first home game in over 18 months against Perth.
The Swans got a late win against St Pats last week, giving Savage confidence heading into a home clash.
"It was a tough game, tough conditions against a quality opponent and someone we've had big games against in the past," he said.
"To get a win on their home deck round one was obviously a fantastic start."
The tough draw continues for Danny Bennett's Magpies having played Old Scotch, Lilydale and East Coast as his young group gels.
"We are confident, it's going to be a tough game though, East Coast are a quality team as well and it's the first game at home for 18 months for them, so they are going to be up and about that's for sure," he said
"We'll go down and continue to try and improve and we are just taking it game by game at the minute."
Sitting at 2-0 after playing the early-season match, Old Scotch face fellow undefeated side Meander Valley.
Admitting last week's win may have been a surprise to some, Thistles coach Brayley Coombes said they will stick to their processes this week.
"Playing away from home is always a challenge, we've got a couple of forced changes with blokes being away but the nucleus of our players are still there.
"We are looking forward to the challenge and I'm confident if we stick to our tasks, we'll get the win."
Meander Valley's win saw them start the season positively for the first time in several seasons, keeping coach Damien Rhind happy.
"We want to make sure we keep a good account of ourselves," he said.
"We marked this game in as a game where we should be more than competitive and have a good chance of taking the four points."