St Marys Pass is down to one lane of traffic after a rock fall caused the road to become partially blocked.
The rock fall occurred about one kilometres from the top of the pass, which connects St Marys and Scamander.
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Tasmania Police released a statement just after midday encouraging motorists to avoid the area, if possible.
"The relevant authorities have been notified and are working to clear the area," the statement reads.
"Motorists are asked to exercise caution in the area and always drive to the conditions."