The cause of a multi-vehicle crash in the state's South which has resulted in the death of a man and a girl is under investigation.
Tasmania Police Inspector Jason Elmer said the collision occurred on Algona Road near Blackmans Bay just after 8.35am on Thursday morning.
He said a white bus which was travelling north collided with a black sedan which was travelling south.
"As a result of that collision, the sedan has then collided with another two vehicles that were also travelling north," Inspector Elmer said.
"It was a severe impact.
"Tragically, as a result of the collision the male driver and female child, a rear seat passenger, were pronounced deceased at the scene."
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Inspector Elmer said as the cause of the accident was still being investigated he was unable to provide any further details.
He did not disclose the age of the deceased female.
Police later revealed it was a 41-year-old man and his young daughter from the Kingborough area who had died.
The driver of the bus has been transported to the Royal Hobart Hospital with non-life-threatening injures and a female driver who had been driving one of the other vehicles has been taken for a medical assessment.
There were no passengers on the bus at the time of the crash.
The road will remain closed as crash investigation officers determine the cause of the collision.
Inspector Elmer said witness accounts and drone footage would inform the investigation.