The chief executive of WorkSafe Tasmania Mark Cocker has resigned, effective immediately.
The secretary of the Department of Justice, Ginna Webster, said the resignation was not due to "issues that have been aired in the media in recent weeks".
WorkSafe Tasmania was in the spotlight for banning the Bob Brown Foundation from protesting in forests due to safety concerns.
The prohibition was then set aside in the Hobart Magistrates Court, and the Greens referred to the matter to the Integrity Commission.
Ms Webster said the position would be filled by Robyn Pearce, the director of industry and safety with WorkSafe Tasmania, on an acting basis while a process is undertaken to fill the position.
"I would like to stress that Mr Cocker's resignation has not arisen as a result of any wrongdoing on his or anyone else's part in relation to issues that have been aired in the media over recent weeks," she said.
."I thank Mr Cocker for his contribution during his time in the role and wish him well for the future."
Unions Tasmania secretary Jessica Munday said it was not the ideal time for the state to be without guidance on workplace health and safety.
"The Covid-19 pandemic is the biggest health and economic issue that most of us have faced in our lifetimes, but it is also one of the biggest workplace health and safety issues too," she said.
"Every workplace across the State has to do things differently right now if they're serious about keeping workers safe. Some workers are at greater risk of exposure to Covid-19, like health workers, transport workers, and cleaners, to name a few, but all work places need to be taking measures to implement safe systems of work with the threat of the pandemic hanging over them.
"This is when we need strong leadership from the work health and safety regulator to ensure that employers are fulfilling their duties to keep workers safe."
IN OTHER NEWS: