Vice-Chancellor Rufus Black has revealed 200 of its courses have no students enrolled in them.
The university on Tuesday made an announcement that it would accelerate its five-year strategy, part of which involves cutting back its course offerings from 514 to 120.
The new course structure will be confirmed mid-year and the expedited move, in part, a response to uncertainty around the coronavirus outbreak and the university's ongoing over-reliance on an international student in-take.
In an email to students, Professor Rufus Black said 200 of its courses had no students enrolled in them.
It said a further 200 courses had an average of less than five students.
"We want to be focused on the courses that students want to do, giving them the best possible experience," the email read.
"We can provide better for that when we are focused on the areas students are excited about and are important to Tasmania."
"If you are in a course with us or if you intend to enrol in a course with us for 2020, your journey is safe.
"You will be supported to your graduation, provided you meet the requirements of the course."
Tasmanian University Union president Braydon Broad said there had been months of discussion by various committees about why certain courses remained on the books and how the enrolment process could be simplified.
He said the main concern had always been a particular student's pathway to graduation.
Mr Broad said he was confident that students enrolled in courses that would eventually no longer exist would be protected based on Professor Black's commitment.
"The TUU will be here to hold them accountable to that," he said.
"A lot of students have been hindered by both stages of the enrolment process which have caused some to drop out from the beginning.
"The most important thing here is to simplify the way we access learning material and make the enrolment process as simple as possible."
Premier Peter Gutwein said he was made aware the university would restructure its courses late last week.
"They have for a long period of time offered a significant number of courses for a small university," he said.
Mr Gutwein said the university had confirmed to him that there would be no delays or changes to the Northern Transformation project for the Inveresk and Burnie campuses.
"I've had very clearly put to me by the university that [the project] is fully funded that there are no concerns with that in terms of the investment and the time frame," Mr Gutwein said.
Tasmanian Chamber of Commerce and Industry chief operating officer Colleen Reardon said it was vital for the university to remain sustainable.
"We support streamlining the University's offering to ensure it closely aligns with the needs of students and the broader community, including the business community," she said.