A truck carrying an 80-metre wind turbine blade has rolled over on Highland Lakes Road at Apsley.
The rollover happened about three kilometres west of the Lower Marshes Road junction about 7am on Thursday morning.
Emergency services are at the scene, with motorists advised the road will be closed for at least 12 hours while crews work to clear the scene.
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Motorists are advised to avoid travelling in the area.
Anyone with essential travel is asked to use an alternative route.
Tasmania Police said no injuries had been reported at this stage.