The Tasman Highway at Buckland has been reopened.
One person was transported by air to Hobart with unknown injuries.
Emergency services are responding to a serious single-car crash near Buckland on the state's East Coast.
The incident occurred around 5050 Tasman Highway, with this section of the highway closed to allow the Westpac Rescue Helicopter to land at the scene.
Motorists are asked to avoid the area or divert through Levendale until the scene is cleared.