A 56-year-old woman has died following a two-car crash at Railton in the state's North West on Saturday morning.
Emergency services were called to the scene on Kimberley Road about 10am.
Acting Sergeant Adam Medhurst said initial investigations indicated the woman, who was driving a blue Suzuki sedan, may have lost control of her car before colliding with a Subaru wagon.
The cars crashed on a corner, causing the sedan to roll before coming to rest on the side of the road.
The woman, from Railton, died at the scene.
She was the sole occupant of the car.
The driver of the Subaru and one passenger were taken to the North West Regional Hospital with non-life threatening injuries.
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Acting Sergeant Medhurst said speed and road conditions were not believed to be a factor in the crash.
Police remained on the scene for several hours investigating the cause of the crash.
Kimberley Road between Hardwick and Maloney roads were also closed for several hours.
A report is being prepared for the coroner.
Police are seeking information from anyone who may have witnessed the blue Suzuki prior to the crash.
Anyone with information can call police on 131 444, or contact Crime Stoppers anonymously on 1800 333 000 or online at crimestoppers.com.au.
"Our thoughts are with the loved ones of the woman who died," Acting Sergeant Medhurst said.
There have been 20 fatal road crashes in Tasmania so far in 2019, compared to 19 at the same time last year.