Seven players through a mix of injury and rest are forced to sit out the anticipated TSLW crosstown derby.

"The young ones are starting to feel the pinch of the physicality, the long season, the training regime," Bombers coach Dean Smith said. "We've got a squad of 27 and we're down to our bare 20."

Onballer Ebony Barrenger, full back Hannah Grima, state player Ella Maurer and last week's best defender Renee Wilson are the key losses.

The Bombers are coming off a huge month after a record win over Lauderdale, an upset against Clarence and tough defeat to Glenorchy.

Smith said facing the Blues with three AFLW stars and are "years ahead of us" will accelerate the development.

"The best thing when we play Launceston, still being undefeated, like last time, is we put young girls on big-name players. That's what we do again - we throw them that challenge," he said.

Blues coach Angela Dickson wants a more clinical effort than their 48-point win in their inaugural clash that included 19 shots to just one.

"We started slow, we weren't switched on, our skills weren't where we needed to be and even though we got the four points, we walked away just really disappointed with how we performed on the day," she said.

"We're looking at this as a bit of a redemption game."

A fresher Launceston will be bolstered by the return of captain Ashlee Carey and North Melbourne pair Daria Bannister and Chloe Haines.

But Dickson said the Blues will need the reinforcements.

"North play a different style of footy to other teams," she said. "They're really more physical; skill-wise they're not quite there yet, but they like to create the contest and have the ball in close and play crash-and-bash."