Operation Gold was carried out by more than 100 police officers during a coordinated search of nine properties on Wednesday.

Six people have since been charged with trafficking in a controlled substance, with police seizing three firearms and more than $25,000 worth of cash.

Police also seized 2.5 ounces of methamphetamine and 50 individual deals packaged for sale, along with about 450 grams of cannabis and 35 individual deals.

A vehicle believed to be involved in the investigation into the murder a Gagebrook man, Jarrod Leigh Turner, was also seized from a Moonah premises.

Mr Turner, 22, was allegedly murdered near Colebrook Road at Richmond on April 14.

Detective Inspector Doug Rossiter said there was a relationship between the operation and the ongoing investigation into what happened to Mr Turner, with police to undergo a full forensic examination of the car.

"It is not the principal vehicle that is involved. This is a vehicle that we believe has some relevance to the murder investigation and we are examining it for that purpose," he said.

Detective Inspector Kate Chambers said the operation was a significant disruption to organised crime.

"Every street deal seized by police counts. It's one less deal of illicit substance available to our families, friends and our community," she said.

"Police not only work hard to seize illicit substances, they also work to disrupt syndicates and networks responsible for the distribution of them."