Drugs, alcohol and a medical condition are being investigated as possible causes of a fatal crash in the state's North on Sunday night.
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A 43-year-old Queensland man died when his Toyota HiAce campervan crashed head-on into a prime mover on the Tasman Highway at Nunamara, about one-kilometre west of the Mount Barrow Road turn off.
The truck driver, a 27-year-old man from Nubeena, was taken to the Launceston General Hospital with minor physical injuries.
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Crash investigator Senior Constable Michal Rybka said the van was driving on the incorrect side of the road for some time before the crash.
"We are still investigating that but we believe a member of the public had been following the vehicle and trying to signal it to pull to the correct side for quite some time," he said.
Next of kin has been notified.
The crash happened on the eve of the National Road Safety Week, prompting a reminder from police to all drivers.
"Be alert, don't drink drive, obey the speed limits, wear your seatbelts and be attentive," Senior Constable Rybka said.