SES volunteers will be working at the long weekend to help make sure drivers get home safely, with driver reviver sites operating on Easter Monday, April 22, from 10am to 4pm.
Sites will be located at Parramatta Creek on the Bass Highway, between Latrobe and Deloraine; Fossey River on the Murchison Highway near Mt Pearce; Sideling Outlook on the Tasman Highway between Launceston and Scottsdale; Franklin River on the Lyell Highway near Mt Arrowsmith.
Police, Fire and Emergency Management Minster Michael Ferguson said road safety was everyone's responsibility.
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"We know that Easter is one of the busiest times on our roads so we urge all drivers to take advantage of a driver reviver site on Monday or simply take a rest break during any long trip," he said.
"We are asking drivers to be especially careful this year and keep the 'Fatal Five' in mind every time they get behind the wheel.
"In short, we want people to buckle up, watch their speed, stay under the alcohol limit, pay attention to the road and rest if they are tired."
Tasmania Police will be targeting speeding, mobile phone usage and drink and drug driving.
As of April 16, there have been 10 deaths on Tasmanian roads and 89 serious crashes, compared to 12 fatalities and 82 serious crashes at the same time last year.
This year's Easter road safety campaign will run from Thursday, April 18, to Tuesday, April 23.