Sue and Jack Goss have five children, 16 grandchildren and 11 great-grandchildren.
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The couple have also taken about 96 foster children of varying ages into their care since 1975.
But after nearly 50 years of foster care, the Goss' have decided to retire.
To commemorate their service in Northern Tasmania, Out of Care North hosted a celebratory barbecue to thank them for decades of support.
Mrs Goss said it was a bit sad that their foster days were coming to an end, but she has a lot of fond memories to look back on.
She said it was the importance of taking care of children in need that first led her to foster care.
"The need for kids to need somewhere to go and the love for kids and it just snowballed from there," she said.
The Goss' last two foster kids are Jamie Macqueen and Alexis Hefferon, who will leave their care once they turn 18 years old.
The Goss' have cared for both Jamie and Alexis since they were babies.
"[I] wouldn't change a thing," Mrs Goss said.
"Some [foster kids] have been short term and some were little tots.
"I hope we've made a difference to some of them."
Out of Home Care acting team leader Tim Mischlewski said the barbecue was a great way to show appreciation to not only the Goss' but all who take in foster children.
"It's incredible what she's [Sue Goss] done," Mr Mischlewski
"She's done an amazing job to be able to have that many kids come through her door.
"We appreciate the work they do and our system couldn't run without them."