Tasman Highway has been closed about 5 kilometres south of Elephant Pass after a semi-trailer rolled over on Monday morning.
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Tasmania Police arrived at the scene about 9.40am and consider the accident "serious".
An ambulance has been called and "it does look like it's serious", but no further information is available about the driver's condition at this stage, a Tasmania Police spokesman said.
Police advised there was a "significant road closure" and motorists should avoid the area.
Traffic cannot travel north out of Bicheno or south from the bottom of Elephant Pass.
The National Heavy Vehicle Regulator has been notified.
More information to come.
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Johanna Baker-Dowdell
Johanna has more than 22 years experience as a journalist for newspapers, magazines and online publications.
Johanna has more than 22 years experience as a journalist for newspapers, magazines and online publications.
