A truck carrying six tonnes of waste has rolled over near the Batman Bridge.
The incident happened at the intersection of the East Tamar Highway and East Arm Road about 1.30pm on Friday.
Police and Worksafe Tasmania are at the scene.
A slip lane from the East Tamar Highway onto the Batman Bridge will be closed for several hours as a result of the incident.
Motorists travelling in the area can expect lengthy delays as emergency services clean up the scene.
Police said no injuries have been reported as a result of the rollover.