Tasmania Police said a male resident of Main Street was heading to work at around 5:30am when he saw three men acting suspiciously near his house.

Police said the resident turned around, saw the men enter onto his property and so drove back to his driveway to confront them.

"When he did this, he struck one of the males who has sustained a broken leg. The male was incapacitated and police and ambulance attended shortly after," Police said in a statement.

"The other two males ran from the scene.

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Police said the resident was interviewed by detectives and the injured man was treated for a broken leg at the North West Regional Hospital.

"The owner will not be charged and the injured male will be spoken to after he gets out of surgery this afternoon," police said.

"The investigation will be ongoing."

Police are calling for anyone who saw the incident or anyone acting suspiciously around Main Street in the early hours of Thursday morning.

The group of men were wearing dark clothing and carrying backpacks.

"The two males who fled the scene have not been identified, although property was dropped by the group as they fled which may lead to identification," Police said.

Information can be passed on to police by calling 131 444 or anonymously to Crime Stoppers on 1800 333 000 or online at www.crimestopperstas.com.au.