Emergency services are at the scene of a ‘serious’ crash on the East Derwent Highway at Rose Bay.
Police said a pedestrian was hit by a bus near the Yolla Street intersection about 9.30am on Friday.
The pedestrian was seriously injured, police said.
The left east-bound lane on the Tasman Bridge is closed to traffic.
The exit from the Tasman Highway at Rosny has also been closed.
Motorists travelling to Lindisfarne should go via Flagstaff Gully Road.