Update at 7.30pm: Police have confirmed that one person has been airlifted to the Royal Hobart Hospital.
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Police said they could not give further details on the person or the types of cars involved.
Police said the road was still closed at this stage.
Earlier: Tasmania Police and emergency services are currently at the scene of a two vehicle crash at the intersection of Sheffield Road and Cornwall Road at Acacia Hills.
Police said the road was closed at the location and diversions were in place.
Police said they did not know how long the road closure would be in place for.
It is unknown whether anyone has been injured in the crash.
More to come...