Three people have died on the state’s roads on Thursday.
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Emergency services were alerted to a serious crash, the third of its kind on Thursday, at 9pm.
The crash was between two vehicles, a Mitsubishi Magna and a Blue Holden Commodore, on Pirie Street, Newtown at the intersection of Roope Street.
Police say the impact forced both cars to the adjacent footpath.
The driver and front passenger of the Magna fled the scene prior to the arrival of emergency personnel.
The 42-year-old female driver of the Commodore was trappedin the wreckage, requiring an extensive extraction by Ambulance Tasmania and Tasmania Fire Service personnel.
She was transported to the Royal Hobart Hospital and was pronounced deceased shortly after arrival.
The 40 year old male front passenger of the Commodore has been taken to hospital with abdominal injuries and remains in a stable condition.
Both vehicles were examined by Crash Investigation Services, Forensic Services and Hobart CIB, specifically in an effort to identify the occupants of the Magna.
Police are currently conducting investigations on a specific line of enquiry regarding their identity.
A report will be prepared for the coroner.
Police are interested in hearing from any member of the public who may have observed the Grey Mitsubishi Magna prior to this incident or who have any knowledge as to the identity of the driver or passenger of this vehicle.
Information can be provided anonymously by calling Crime Stoppers on 1800 333 000 or online at crimestopperstas.com.au.