More than $100 million will be invested in rejuvenating Launceston's CBD and improving its health services.
The top initiatives for the city handed down in Thursday's state budget include $35.8 million to fund the John L Grove rehabilitation centre and $20 million for the reopening of ward 4D at the Launceston General Hospital.
To round out the top three expenditure spends for Launceston, the state government has also allocated $50 million for the relocation of the University of Tasmania campus from Newnham to Inveresk.
The $50 million is in total and includes funding already allocated to the campus moves in Burnie and Launceston.
A total of $7 million over two years will assist the redevelopment of the CH Smith site to establish new offices that will be leased by the government.
The infrastructure investment will assist with the revitalisation of the site and add to Launceston's leased office portfolio.
There was nothing unexpected in the spending deals for the North, with Launceston's federal City Deal and the City of Launceston-developed City Heart initiative also featuring.
East Coast tourism was also given a boost among the initiatives for the North, with six out of nine initiatives focused on the sector.
The biggest spends on the East Coast for tourism was $6.3 million to extend the Great Eastern Drive and $1.8 million for restoration works on Maria Island.
Already announced budget initiatives $11.4 million to construct a new hospital at St Helens and $1 million for the St Helens bike trail network were also committed to.
Northern Tasmania will also benefit from infrastructure spending, with $3 million allocated for a new ambulance station at Campbell Town, $800,000 allocated for the Blue Derby mountain bike trails, and upgrades to roads and bridges.
Bridport Road bridges will be updgraded with $1.95 million allocated in the budget and $1. 1 million was allocated to upgrades to bridges on the Midland Highway.
Support for the Launceston Ten and the Stan Siejka Cycling Classic was also included.