A 60-year-old Railton man has died following a single-vehicle crash at Brandum on Saturday night.
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Tasmania Police attended the crash on Highland Lakes Road about 8pm.
Officers provided first aid to the driver, but he died at the scene.
A 58-year-old woman was airlifted to the Launceston General Hospital in a serious but stable condition.
Two other adult passengers were transported to hospital with non-life threatening injuries.
Tasmania Police said speed appeared to be a factor.
Investigations into the crash are continuing and a report is being prepared for the coroner.
Anyone who witnessed the crash or observed a silver Mitsubishi Triton utility in the area should contact Crash Investigation Services via Crime Stoppers on 1800 000 333 or 131 444.