Devonport Police are concerned for the welfare of 68-year-old Geoffrey Cecil Best, who left the Karingal Nursing Home at Devonport shortly after 8am on Friday.
Mr Best has not yet returned to the home.
Police said Mr Best takes his daily walk from the nursing home at the same time and is known to frequent the Devonport CBD.and he also walks around the streets near to the home.
When he was last seen he was wearing a cowboy style hat, an older style brown coat, dark pants and light footwear.
Mr Best is described as having silverfish grey hair, is approximately 168cm tall and of medium build.
When last seen he was also wearing his prescription glasses and police said he may be disorientated.
If Mr Best is sighted call police on 131444.