3.45pm UPDATE: Police advise the highway is now open to traffic.
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12pm UPDATE: One person has died following a crash on the Bass Highway.
The highway will remain closed to traffic for a significant time.
EARLIER: The Bass Highway at Devonport is closed in both directions after a serious car crash.
The crash is blocked the highway at the Latrobe roundabout, Port Sorell Road roundabout and the intersection of Winspears Road and the highway.
Police reported the crash just after 11am on Thursday.
Police say three cars are involved, and a female has been to taken to hospital.
The highway will be closed for a ''significant time'', say police.
MORE TO COME