One lane of the Bass Highway near Smithton will be closed for several hours this afternoon after a truck roll-over.
A cattle truck rolled in the highway's west-bound lane, near Mella Road, about 3.30pm.
Traffic is being filtered through one lane, creating delays. Motorists are asked to drive with caution.
While the truck driver was not injured, at least 10 animals were killed in the crash.
The remaining animals are in a paddock next to the road.