4.20PM UPDATE: Detective Senior Sergeant Gillies said there was no evidence to suggest that the burglary was a targeted attack.
He said that business and residential burglaries in the North had decreased recently, and the firearm theft was not indicative of any increase in crime.
EARLIER: POLICE are investigating the theft of 14 firearms from a Newstead home yesterday.
The firearms were registered and stored in an approved gun safe, but it appeared the safe was opened using a key found at the residence, police said.
The guns, a gold-coloured 2007 Holden Calais sedan, a small amount of jewellery and laptop computers were stolen from the house in Clementina Street between 12.30pm and 2.15pm.
Detective Sergeant Michael Gillies said it appeared the offenders arrived at the house on foot and left in the Holden Calais.
He urged anyone who had seen the vehicle or anyone acting suspiciously in Clementina Street yesterday afternoon to call Crime Stoppers.
"This is also a timely reminder for registered gun owners to not only store their guns correctly but to keep their gun safe keys on them or in a secure location," he said.
Anyone with information that could help police was asked to contact Crime Stoppers on 1800 333 000 or Launceston CIB on 6336 3911.