Tasmania Police have concerns for the welfare of 39-year-old Hobart woman Theresa Marie Bosworth, who was last seen walking through Hobart's Elizabeth Street Mall on Friday.
She is described as being 165 centimetres tall, solid build with fair complexion and light brown collar length hair.
At the time she was wearing an apricot shirt with short sleeves, dark trousers and dark shoes and carrying a black handbag.
Police are concerned for her welfare as she is without her required medication.
Anyone who has information about her whereabouts is asked to contact Hobart Police on (03) 62302 384 or via Crime Stoppers on 1800 333 000.